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Organic compounds that contain a carboxyl group bonded to an organic functional group; carboxyl groups consist of a carbonyl group bonded to a hydroxy group. Includes compounds that are derived from carboxylic acids.
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(E/Z)-Zotiraciclib citrate is a potent inhibitor targeting CDK2, JAK2, and FLT3. This compound is supplied as a solid, appearing off-white to light yellow, and is intended for research use only.
Potent CDK2, JAK2, and FLT3 inhibitor
High purity: 99.83%
Molecular weight: 564.59
Store at 4°C, sealed, away from moisture
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Gefapixant citrate is a P2X3 receptor antagonist provided as a concentrated solution for laboratory research. The reagent is supplied at 10 mM in DMSO (1 mL) and is intended for in vitro pharmacology and biochemical studies, with analytical documentation available from the manufacturer.
Ready-to-use 10 mM solution in DMSO, 1 mL.
High purity (99.2%) suitable for research applications.
Supports in vitro P2X3 receptor pharmacology and biochemical assays.
Comes with data sheet, certificate of analysis, and safety data sheet.
For research use only; not for human or diagnostic use.
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Pacritinib (SB1518) citrate is a potent inhibitor of both wild-type JAK2 (IC50=23 nM) and JAK2V617F mutant (IC50=19 nM). It also inhibits FLT3 (IC50=22 nM) and its mutant FLT3D835Y (IC50=6 nM). This compound can be used for the research of acute myeloid leukemia (AML) and myelofibrosis (MF).
Potent inhibitor of wild-type JAK2 (IC50=23 nM)
Potent inhibitor of JAK2V617F mutant (IC50=19 nM)
Inhibits FLT3 (IC50=22 nM)
Inhibits FLT3D835Y mutant (IC50=6 nM)
Used for research in acute myeloid leukemia (AML) and myelofibrosis (MF)
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cGAMP (Cyclic GMP-AMP) diammonium functions as an endogenous second messenger in metazoans and triggers interferon production in response to cytosolic DNA. It activates stimulator of interferon genes (STING), which activates a signaling cascade leading to the production of type I interferons and other immune mediators.
Endogenous second messenger in metazoans.
Triggers interferon production in response to cytosolic DNA.
Activates stimulator of interferon genes (STING).
Activates a signaling cascade leading to the production of type I interferons and other immune mediators.
Promotes the antigen-specific proliferation capacity of spleen cells in mice.
Directly activates murine and human dendritic cells *in vitro*.
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